Jacob Blessing the Sons of Joseph is an oil on canvas painting by the dutch painter and etcher Rembrandt van Rijn. It was painted in 1656. The subject is taken from the book of Genesis, chapter 48. The dying patriarch Jacob is shown blessing his grandsons Ephraim and Manasseh. Their father Joseph and his wife Asenath stand behind the children. This painting (173 x 209 cm) is currently housed in the Staatliche Museen, Kassel.