Pellegrino Tibaldi and San Sebastiano (1577). In Milan he worked also as a civil architect, projecting the Spinola, Erba Odescalchi and Prospero Visconti palaces. In 1575 he was commissioned by Cardinal Tolomeo Gallio the construction of Villa d'Este on the shores of Lake Como.
In 1586 he went to Spain, where he followed and replaced Federico Zuccari as main court painter. He painted in the lower cloisters of El Escorial at the request of King Philip II. His greatest work were frescoes in the library. After nine years, he returned to Italy and was appointed architect of the Duomo of Milan until his death in Milan in 1592.
Pellegrino's brother, Domenico Pellegrino Tibaldi was an engraver active in Bologna. Among his pupils were Orazio Samacchini, Lorenzo Sabbatini, and Girolamo Miruoli. His son Domenico Tibaldi is known mainly as an architect in Bologna.

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