Sofonisba Anguissola to cultivate and perfect their talents. Four of the sisters (Elena, Lucia, Europa and Anna Maria) became painters, but Sofonisba was by far the most accomplished and renowned. Elena abandoned painting to become a nun. Both Anna Maria and Europa gave up art upon marrying, while Lucia Anguissola, the best painter of Sophonisba's sisters, died young. The remaining sister, Minerva, became a writer and Latin scholar. Asdrubale, Sophonisba's brother, studied music and Latin, but not painting.
Her aristocratic father made sure that Anguissola and her sisters received a well-rounded education that included the fine arts. Anguissola was fourteen when her father sent her and her sister Elena to study with Bernardino Campi, a respected portrait and religious painter of the Lombard school. When Campi moved to another city, Anguissola continued her studies with painter Bernardino Gatti (known as Il Sojaro). Anguissola's apprenticeship with local painters set a precedent for women to be accepted as students of art. Dates are uncertain, but Anguissola probably continued her studies under Gatti for about three years (1551–1553).

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