George Stefanescu-Râmnic was born in 1914 in the commune of Plăineşti, Romania. His father was descended from a Macedonian family from Bitola, Macedonia, and his mother was originally from the commune of Crucea de Jos, Vrancea County. Stefanescu-Râmnic initially attended the secondary school in Râmnicu Sărat, where his art teacher recommended him to the church painter Constantinescu. After school, he became Constantinescu's apprentice. In 1933, after receiving his baccalaureate, he moved to Bucharest and studied at the Academy of Creative Arts in the class of Nicolae Dărăscu. In 1936, he had his first solo exhibition in a Bucharest art gallery and also took a study trip to Vrancea and Balcic. In 1937, he attended artillery officer's school, had an exhibition in Craiova with the writer Ion Ionescu, and began to sketch designs for women's clothing and fashion accessories for a Bucharest fashion house. He also became a member of Sindicatul Artiștilor din România (the Union of Romanian Artists) and became a student at the well-known private art seminar 'Zapan'. His professors there were well-known painters such as Lucian Grigorescu, Platon Cazanovici, and Mihail Gheorghiță. In 1938, together with the fresco painter Alexandru Mazilescu, he worked painting murals. In Bukovina, he had the opportunity to observe the well-known wall paintings of the painted monasteries